Vital Facts On Marriage Records

As ordered by the laws of the State, all vital public files of Illinois are stored at the State’s Department of Public Health, Division of Vital Records. Its archives accommodate different files, including births, deaths, divorces, and Illinois Marriage Records. A specified amount of fee for each file copy has to be paid to the same office via money orders, certified checks or personal checks.

In this State, all requests for accounts pertaining to anyone’s marriage must be forwarded to the County Clerk in the county where the concerned couple were married. Additionally, copies of the same information can also be gathered through the Illinois Regional Archives Depository. An index of marriages that occurred from 1763 to 1900 can also be acquired for free at a government-owned search site online.

By definition, marriage is known as a legally recognized relationship. It is established by a civil or religious ceremony between two people who intend to live together as sexual and domestic partners. The act of marrying normally establishes certain legal obligations between both parties, extending to some family members of the concerned couple. Often viewed as a contract, a nuptial is normally recognized by the state, a religious authority, or both.

Searching for documents that relate this kind of event is just one important way for you to initiate a background check on someone. If you think your partner is not being truthful to you, then this is a good source of information to justify your doubts. It is also beneficial to support any genealogical and historical researches. Furthermore, adopted children, who are looking for their biological parents, can also make use of this document.

In the advent of time, every piece of information you need is now accessible over the Internet already. That means that so long as you have an online computer and a little know-how about browsing the Web, getting answers to your questions will be just a few clicks away. Two major classifications of search sites online are free and fee-based. Picking the latter is highly recommended, though, since it ensures first-rate service for a low-cost only.

It seems that most people now opt to search for Marriage And Divorce Records online than through the traditional methods with those government offices. One of the reasons for that is because it is doable wherever you are provided there’s Internet connection. Undoubtedly, online services offer convenience, privacy, plus a kind of report that is done with much accuracy and immediacy.

Professional and Trustworthy in-Home Caregivers for Your Love One

Taking care of elderly parents or other relatives at home can be difficult. More so if they have a disease that is continuously progressing. If the situation is getting more and more difficult for you to handle, and is affecting the quality of your life, maybe, hiring an in home caregiver is just what you need. There are actually a lot of agencies, individuals, caregivers and nurses who can help and provide the kind of service that suits your need. However, finding the right person to help you takes a lot of consideration.

caregivers of Arizona

Hiring home caregivers is a popular option, explored by many families every year. Some communities have become aware of the increased need for in-house care and have started developing volunteer services, drop in centers as well as help-lines which people can use to seek advice, suggestions and guidance. However, when it comes to hiring in-home caregivers, it can be difficult to know who to hire and where to find the services needed for your family.

Most of us are going to have to deal with this with aging parents or ourselves; what to do about deteriorating health of elderly family members. Some may even be experiencing more advanced forms of senility that require dementia care of Alzheimer’s care. When this situation occurs, find the right way to treat it is essential.

There are a few things you will want to keep in mind when going through this process. For one, if you are selecting a caregiver for an older relative, you will want them to be involved. Having the person receiving the care being a part of the selection process is an essential part of this-even if they suffer from dementia or Alzheimer’s disease. Having their input in these latter instances is important so that you can remind them that they were in fact part of the decision making team. This will validate their caregiver for them in many instances.

You may also need to make a list of what the person receiving care’s needs are and in what areas the caregiver will be helping them in. Not all caregivers have the same list of duties, so this will help you to narrow down your list. Another thing to consider is how long these tasks will take to accomplish. For example, if your elderly loved one only needs help with making meals and bathing, the caregiver can visit for only two hours or so per day. But if their needs are more intensive, you might require more time with a caregiver. It’s best to start out with an extra hour or two than you think that will be needed so that you will not have anything go without being completed. You can always scale back the hours later on.

Another consideration is your loved one’s privacy needs. This is especially the case for people who are functioning at a higher level. Nobody really every wants to be dependent on someone else if they don’t need to, so establishing your loved one’s privacy needs is extremely important. If you think your family member fits into this category, try and give them as much freedom as possible with their in home caregiver and limit hours to only the absolutely necessary amount of time that will be needed.

If you are trying to find professional and trustworthy in-home caregivers of Arizona for your love one that needs special health, I highly recommend you to review the Care from the Heart. They provide in-Home care service in Arizona. Arizona in-home caregivers are going to take good care of your parents and their special needs will give you piece of mind.

All in all, you will want to establish a line of communications. If you cannot find a caregiver that you feel you can talk to and trust on your first try, just keep looking. This is a quickly growing field of employment and as a result, there are a lot of caregivers out there. This is beneficial to you because it allows you more freedom of choice when it comes time to pick the perfect caregiver for your family. If you can’t find a good in home caregiver, it might be worthwhile to discuss assisted living with your elderly loved one. These two types of care cost about the same per year and both offer a good degree of freedom for your loved one.

Protecting Ocean Regions With Robotics

1 INCREASING BURDEN OF CHRONIC ILLNESS AND EVER-AGING GLOBAL POPULATION

With the ever-aging global population and the growing burden of chronic illness, there is an increased reliance on the healthcare system (particularly the biopharmaceutical industry) in order or one to achieve and sustain a high quality of life. According to the World Health Organization (WHO), the burden of human diseases have been rapidly increasing for decades with this trend predominantly contributed by population growth and environmental degradation.

1.2 DEFINITION OF MARINE BIOPROSPECTING

Marine bioprospecting is the search for novel compounds from natural sources in the marine environment. These activities have increased a great deal in the last few years likely in part due to the continued technological advances enabling further oceanic exploration, acknowledgement of the rich generic diversity in the marine biome, as well as the pressure from industry to produce given various blockbuster drugs going off patent. Today, about 18,000 natural products have been reported from marine organisms belonging to about 4,800 named species. The number of natural products from marine species is growing at a rate of 4% per year. The increase in the rate of discoveries is largely the result of technological advances in exploring the ocean and the genetic diversity it contains. Advances in technologies for observing and sampling the deep ocean, such as submersibles and remotely operated vehicles (ROVs), have opened up previously unexplored areas to scientific research. Since 1999, the number of patents of genetic material from marine species has increased at the rate of 12% per year. Marine species are about twice as likely to yield at least one gene in a patent than their terrestrial counterparts. Bioprospecting typically requires the collection of a very limited amount of biomass for the initial discovery. Although further collections may be required after a promising discovery has been made, bioprospecting generally does not involve threats to biodiversity comparable to the large biomass removals involved in harvesting resources for food or mineral exploitation.

1.3 THE SUCCESS OF NATURAL COMPOUNDS IN DRUG DISCOVERY AND BIOPHARMACEUTICAL BACK DROP

Biopharmaceuticals are one of the most impressive achievements of modern science. Many biopharmaceuticals offer high efficacy and few side effects. And there is much more to come: radically new concepts are making it to the market, and the advances keep coming at a rapid pace. The success of natural compounds in drug discovery is unparalleled: for antimicrobial and anticancer therapies, for example, more than 70% of new chemical entities introduced during the period 1981-2002 originated from natural products. It has been estimated by the US National Cancer Institute (NCI) that 1% of samples from marine animals tested in the laboratory reveal anti-tumor potential (which compares favorably with just 0.01% of samples of terrestrial origin). In the last few decades, advances in informatics, automation and imaging technology have made it possible to screen 100,000s – 1,000,000s of small molecules against a specific biological target or cellular assay per day, compared with 10s-100s of compounds tested on animals over many months previously. Growing awareness of the limitations of historically valuable approaches, and breakthroughs in robotics technologies, such as those used in separation and structure determination, have made screening mixtures of structurally complex natural product molecules easier, and have expanded the potential role of natural chemical diversity in the drug discovery process

2 THE OPPORTUNITY

2.1 AUSTRALIA CONTEXT

Australia is one of only 17 mega-diverse countries in the world and is renowned for the uniqueness of its biota. Australia has several features proving attractive to investors and researchers in the natural products area. This includes, not least, access to a diverse and unique biota. More generally, the features of Australia conducive to research and commercial activity include its robust system of law and stable democratic system of government, its stable and resilient economy, transparent and efficient regulatory environment, comprehensive intellectual property protections and high scientific and technological capacity. Australia has remained relatively isolated over time compared to most countries. Consequently, Australia has a high proportion of endemic species – that is, species not occurring naturally elsewhere. For example, in the case of mammals, approximately 83% are endemic to Australia. Australia’s unique marine environment contains the world’s largest areas and highest diversity of tropical and temperate seagrass species and of mangrove species; some of the largest areas of coral reefs; exceptional levels of biodiversity for a wide range of marine invertebrates; and it is estimated that around 80% of the southern marine species occur nowhere else in the world. With only 0.3% of the world’s population, Australia contributes 2.5% of the world’s medical research and 2.9% of global scientific publications (Invest Australia, 2007, p.6). In 2005, Australia ranked eighth in the OECD in terms of the proportion of researchers in the total labor force. This is above the OECD average. On a per capita basis, Australia has a research output twice the OECD average. In terms of biotechnology research, Australia has several dedicated biotechnology research institutes. Australia’s biotechnology industry is steadily growing, with activity across biotechnology fields including biomedicine, agricultural biotechnology, industrial biotechnology and environmental biotechnology. The Australian Government is a staunch advocate of the domestic pharmaceutical industry and has been very supportive in implementing initiatives to grow this sector. By any measure, Australian Government support for research and development in the biopharmaceutical industry has been and looks to continue to be strong.

2.2 MARINE BIOME REMAINS UNTAPPED/UNDER-INVESTIGATED-THUS PROSPECTS FOR NEW AND MEANINGFUL FINDINGS ARE SIGNIFICANT

Today, biopharmaceuticals generate global revenues of $163 billion, making up about 20 percent of the pharma market. It’s by far the fastest-growing part of the industry: biopharma’s current annual growth rate of more than 8 percent is double that of conventional pharma, and growth is expected to continue at that rate for the foreseeable future. Marine bioprospecting has the potential to further drive these trends. The marine biome remains untapped and under investigated, and thus, perfectly poised to drive both topline and bottom line for multiple stakeholders in the biopharma value chain. Investing in biotech R&D has yielded better returns than the pharma-industry average. The current biologics-development pipeline supports an outlook of continued healthy growth. The number of biotech patents applied for every year has been growing at 25 percent annually since 1995. There are currently more than 1,500 biomolecules undergoing clinical trials, and the success rate for biologics has so far been over twice that of small-molecule products, with 13 percent of biopharma products that enter the Phase I trial stage going on to launch. To date, sampling of marine products has primarily occurred in easy-to-reach coastal waters. As a result, 97% of natural products of marine origin are from eukaryotic sources (organisms with complex cells), with sponges alone accounting for 38% of the products. However, the majority of the Earth’s metabolic diversity resides in prokaryotic organisms (single-celled organisms such as bacteria) and over 99% of the microbial community of the ocean remains to be explored, so it stands to reason that many more genetic sequences valuable for products are yet to be discovered. There is a particular interest in marine species that live in extreme environments, such as hydrothermal vents and seamounts (‘extremophiles’). By the end of 2007, only 10 compounds had been reported from Deep Ocean and ocean trench environments, with a further seven identified in 2010. Fewer than 10 marine natural products have so far been reported from hot vent bacteria. Furthermore, if we break down the various ecosystems of our seas and oceans and compare the chemical dynamics, coral reefs have particularly impressive potential. The corals that we see are actually made up of colonies that build up and thrive in an environment where nutrients are low. Although coral reefs only occupy 0.1% of the world’s ocean surface, they are one of the most diverse ecosystems on earth, hosting ~25% of all marine species. The focus on the coral reef ecosystem as a target place for medicinal purposes is not a new concept. As early as the 14th century, coral reefs were a known source for medicines. One practice at that time is the use of fish gall bladder to treat venomous stings from marine organisms. Today, coral reefs have already contributed its name in the pharmaceutical industry as one of the source of biochemical compounds for new drugs and the possibilities are endless. The opportunity moving forward is substantial.

2.3 SPECIFIC EXAMPLES OF SUCCESSFUL MARINE BIOPROSPECTING

2.3.1 Aplidin

One of the early biochemical compounds derived from the sea is Didemnin, a compound isolated for the treatment of certain cancers. This compound was obtained from the tunicate Trididemnum solidum. Unfortunately, Didemin did not survive in later stages of its clinical trials. However, after a series of further exploration, a relative of the former species was discovered to poses similar traits. The tunicate Aplidium albicans possesses the compound Aplidin® which has a similar structure with Didemnin but far less toxic. Aplidin is an anti-tumor, anti-viral and immunosuppressive drug that has been demonstrated to be effective in pancreatic, stomach, bladder and prostate cancers. After undergoing series of clinical test, Aplidin was granted the classification as an orphan drug that specifically treats multiple myeloma and acute lymphoblastic leukemia. In the United States alone, there are over 45,000 people with multiple myeloma and an estimated 15,000 new cases in the U.S. each year.

2.3.2 Yondelis

Yondelis® was developed by the PharmaMar Pharmaceutical Company and was released in the market in 2003. This compound is now sold by Zeltia and Johnson and Johnson. Yondelis contains the active substance Trabectedin. Trabectedin is derived from coral reefs. Specifically from the filter feeding sacs of the small and immobile plant-like invertebrate called sea squirts. Extracts of this reef associated species has been found to contain a treatment for soft-tissue sarcoma and ovarian neoplasm sarcoma. Yondelis was developed as a result of the National Cancer Institute Screening Program for marine plants and animals. Sea quirts were collected from reefs of West Indies and studied in the laboratory at the University of Illinois. The anti-cancer biosynthetic compound was then discovered to be embedded in the symbiotic microorganism within the sea squirts. Yondelis is produced in a semi-synthetic manner, after the extracts from the sea squirts undergo a patented chemical process. This process is less intrusive and less demanding to the natural marine biome. Moreover, even though the usage of Yondelis is only for rare medical conditions such as sarcoma, there is still potential for this product to add a lot of value to the lives of patients and other stakeholders. More and more adopting Yondelis in their prescribing workflow for sarcomas and there are an increasing number of patients who are sensitive to medicines containing platinum and Yondelis is one of the only alternative anti-cancer medicines.

2.3.3 Pro Osteon

There are many indications for a bone graft implant (e.g. fusion of the spine, joints in arms and legs, fractures or gaps in bones caused by trauma or infection, oral surgery). In a typical bone grafting procedure, a synthetic material is shaped by the surgeon to fit the affected area of the bone while pins or screws are used to hold it in place. This material builds a support structure where bone cells can interlace, regenerate and heal. Pro Osteon Implant 500 has a porous microstructure where new tissues and blood cells can grow, thereby stimulating growth and connects fractured bone segments. Generically called “Bone Void Filler” and approved by the FDA in 1992, Pro Osteon Implant 500 is clinically proven to be safe, strong and cost effective. This material is sterile, thereby minimizing adverse reactions from the patient’s immune system rejecting the implant. The effectiveness of Pro Osteon Implant 500 lies in its source. It uses corals from the sea that has the same porous interconnected structure of a typical bone graft thereby mimicking the internal structure of a human bone. After undergoing a patented chemical process, it converts the coral into hydroxyapatite which is a mineral and the chief structural element of a human bone. At this stage, the implant material is now also osteoconductive which facilitates bone cells to weave into the porous structure. After the procedure and the healing process starts, the Pro Osteon Implant will eventually be covered and replaced by bones creating the mended part as strong as it was before. Pro Osteon has great demonstrated efficacy and a safe side-effect profile. The company manufacturing this product is projecting at least $3 billion in sales by 2017. What’s more, the production of Pro Osteon is not completely dependent on farming and extracting corals from their natural habitat. Special techniques have been developed, which require only a small portion of coral to be extracted, while the balance is grown artificially in the lab-thus promoting sustainability and stability of the marine biome.

3 THE CHALLENGES

3.1 HOW TO CONSERVE AND SUSTAINABLY USE MARINE BIOLOGICAL DIVERSITY

Despite the fact that marine bioprospecting is relatively unimposing and the practice does not impose the sustainability risk of various terrestrial techniques, conservationists and the public still have some concerns. For one, very little is known about the conservation status of many species used as sources of marine genetic resources. Further, many species occur in vulnerable and fragile ecosystems. Many are also concerned with what we don’t know in this relatively nascent sub-industry at this point. For instance, the effect on ecosystems of removal of marine genetic resources is poorly understood.

3.2 FEW NATIONS CAN SUCCESSFULLY DO BIOPROSPECTING ON THEIR OWN

Investment in marine biotechnology is not without risk. Sampling at sea costs a minimum of US$ 30,000 per day or US$ 1 million for a month. It typically takes 15 years overall, and an investment of up to US$ 1billion, to go from research to commercial product, due to the fact that many products fail to deliver on early promises. As a result the field is dominated by relatively few nations. Patent claims associated with marine genetic resources (MGR) originate from only 31 countries. Ninety per cent of these patents originate from 10 countries (USA, Germany, Japan, France, UK, Denmark, Belgium, Netherlands, Switzerland and Norway), with 70% originating from the US, Germany and Japan. Despite the high levels of investment required in R&D, biotechnology is a lucrative and important industry.

3.3 THE CURRENT UNCERTAIN AND UNPREDICTABLE LEGAL AND REGULATORY FRAMEWORK DISCOURAGES INDUSTRY (I.E. BIOPHARM COMPANIES) FROM INVESTING THEIR EFFORTS INTO BIOPROSPECTING

The potential of marine bioprospecting has become the subject of international policy debate (particularly for areas beyond national jurisdiction). One central question is whether the potential benefits from marine bioprospecting ought to be shared by the entire international community or only by the States or individual corporations with the capacity to exploit them. Various groups are looking at this in order to configure the most sensible set of policies to balance the need to promote innovation and technological/biopharmaceutical advances, with the need to make sure all stakeholders in the value chain are appropriately compensated, along with the need to ensure the longevity of these natural marine habitats. Increasingly, individual nation-states are establishing policies that dictate the way in which protected marine habitats in their jurisdiction may be used for bioprospecting and other scientific and commercial pursuits.

3.4 COSTS OF BIOPHARM/BIOTECH DISCOVERY

There are operational and technological challenges to bioprospecting and biopharmaceutical discovery in general. Reproducing large molecules reliably at an industrial scale requires manufacturing capabilities of a previously unknown sophistication. Consider this: a molecule of aspirin consists of 21 atoms. A biopharmaceutical molecule might contain anything from 2,000 to 25,000 atoms (Exhibit 1). The “machines” that produce recombinant therapeutics are genetically modified living cells that must be frozen for storage, thawed without damage, and made to thrive in the unusual environment of a reaction vessel. The necessary sophistication comes at great cost. Large-scale biotech-manufacturing facilities require $200 million to $500 million or more to build, compared with similar-scale small-molecule facilities that may cost just $30 million to $100 million, and they can take four to five years to build. As the number of products rises and new process technologies such as continuous manufacturing are introduced, the complexity of biopharma operations and the biopharma supply chain will increase.

Illinois Health Classification

Enjoyment of a hot cup of tea and health benefits bundled into one bag is weight loss tea. Weight loss tea is one of the most appreciated health products on the market today. It contains an anti-oxidant called EGCG that is supposed to increase the body metabolism by up to 4%, act as an appetite suppressant and delays deposits of fat from developing in your body.

In particular tea helps to prevent cancers and slow down the development of certain de-generative diseases such as Parkinson’s and Alzheimer’s disease. It is also helpful in case of weak memory and other ailments such as itching and swelling. Another very interesting quality of tea is that it is believed to make you heart rather arteries stronger and aids to keep a glow on your face and make you look younger. So that means consuming weight loss tea will not only make you slimmer, but will also clear your skin, boost energy and will give your face a healthy, radiant and clear glow.

Tea is a 100% organic product which has its roots lying in the thousands of years old Chinese medicinal practices. It is extracted by the process of isolating powerful anti-oxidants using water or steam followed by condensation and drying. The extract thus obtained is usually in the powder form and sometimes also used in fat burning and diet pills. One more functional attribute of tea is to keep your body hydrated which makes you crave less for beverages.

Weight loss tea, sometimes also referred as green tea is specifically aimed at acting as a diuretic and aids elimination of bodily waste products. Whereas green tea is like black tea and contains caffeine which may or may not promote weight loss depending on the strength of the tea. Since it’s super concentrated, it’s entirely possible to consume a hundred cups of tea a day using green tea extract. Some research indicates this would completely negate any positive effects and may even be harmful.

In fact there are several types of weight loss tea and green tea could be one of those. All teas come from the same plant (Camellia sinensis), and can be grouped into four main types: white tea, green tea, Oolong tea, and black tea. Tea type is determined by its oxidation method. The more oxidization a tea undergoes during processing, the darker it becomes. Heavily oxidized tea is very dark with more flavors and more caffeine. Green tea is not oxidized. This means it has less aroma and caffeine, but it retains much more of its powerful nutrients and antioxidants.

Green tea and weight loss:

One of the more exciting and well known benefits of green tea is its ability to aid in weight loss. Along with giving you an extra energy boost, green tea stimulates the metabolism while simultaneously blocking fat absorption. In 2006, a study published in the European Journal of Clinical Nutrition found that tea is a healthier choice than almost any beverage including water.

Pu-erh and Oolong teas for weight loss:

Oolong teas should be brewed around 90 to 100 C (194 to 212 F), and the brewing vessel should be warmed before pouring in the water. Yixing purple clay teapots are the traditional brewing-vessel for oolong tea. For best results use spring water, as the minerals in spring water tend to bring out more flavors in the tea. High quality oolong can be brewed multiple times from the same leaves, and unlike green tea it improves with reuse. It is common to brew the same leaves three to five times, the third steeping usually being the best.

Pu-erh tea is also called Pu’er tea. Pu-erh teas require boiling water for infusion. Some prefer to quickly rinse pu-erh for several seconds with boiling water to remove tea dust which accumulates from the aging process, then infuse it at the boiling point (100C or 212F), and allow it to steep from 30 seconds to five minutes.

Black tea for weight loss:

In the West, water for black tea is usually added near boiling point 99 C. Many of the active substances in black tea do not develop at temperatures lower than 90C. Lower temperatures are used for some more delicate teas. The temperature will have as large an effect on the final flavor as the type of tea used. The most common fault when making black tea is to use water at too low a temperature. Since boiling point drops with increasing altitude, it is difficult to brew black tea properly in mountainous areas. It is also recommended that the teapot be warmed before preparing tea, easily done by adding a small amount of boiling water to the pot, swirling briefly, before discarding. In the West, black teas are usually brewed for about 4 minutes and are usually not allowed to steep for less than 30 seconds or more than about five minutes. In many regions of the world, however, boiling water is used and the tea is often stewed. For example, in India black tea is often boiled for fifteen minutes or longer as a strong brew. The popular varieties of black (red) tea include Assam tea, Nepal tea, Darjeeling tea, Nilgiri tea, Turkish tea and Ceylon tea.

Herbal tea for weight loss:

The term herbal tea usually refers to infusions of fruit or herbs containing no actual tea, such as rosehip tea or chamomile tea. Alternative terms for this are tisane or herbal infusion, both bearing an implied contrast with tea.

Apart from this classification you can also distinguish the weight loss tea by their flavors or the content of polyphenols and EGCG in them. Polyphenols block formation of non-melanoma skin cancer.

Researchers have also proved the following benefits of consuming tea:

ORAL WELLNESS

Researchers at the University of Illinois in Chicago found that polyphenols in Green tea inhibit the growth of bacteria that cause bad breath. These antibacterial properties also help the teeth and gums. In fact, a Japanese University found that regular consumption of tea strengthened participant’s teeth and helped to prevent tooth decay.

AVOID AGING OF SKIN

Along with fighting the signs of aging, green tea also helps with less obvious forms of aging as well. A Japanese University study found that drinking more than 2 cups of green tea per day slashed the odds of cognitive impairment in elderly patients by 64%.

WARD OFF ARTHRITIS

Study results reported in the Proceedings of the National Academy of Sciences shows that polyphenol antioxidants in green tea benefits suffers of arthritis by reducing the incidence and severity of the disease. EGCG protects cartilage destruction and reduces joint swelling and pain. This leads many scientists and health professionals to recommend green tea as a legitimate remedy for treating arthritis.

STRONG IMMUNE SYSTEM

Catechins, the antioxidant polyphenol compounds, have been shown to have a major impact in your immune system. Research conducted by the Brigham and Women’s Hospital in 2003 revealed that thiamine, found in green tea, boosted the activity of the gamma delta T cells that form part of our adaptive and innate immunity. The study followed a group of coffee drinkers and a group of tea drinkers who each drank 600ml of their drink daily. Blood samples taken four weeks later quite clearly showed that production of these anti-bacterial proteins were five times higher in those drinking tea.

So Yes! Weight loss tea can help boost your metabolism, but green tea alone cannot help you lose weight. You should follow a weight regulating diet plan also to make sure you get that desired shape and look that you always wanted to have!